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epitalon

Evidence is being populated by Grok web

Overview

Evidence is being populated by Grok web search.

References (7)
  1. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties“Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution. During the last 25 years, this compound has been extensively studied using in vitro, in vivo, and in silico methods. The results of t”
  2. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity“Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. ... Our data suggests that epitalon can extend telomere length in normal healthy mammalian cells through the upregulation of hTERT mRNA expression and telomerase enzyme activity.”
  3. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging“Nine peptides were identified spanning diverse aging interventions: metabolic restoration (tirzepatide), telomere biology (epitalon), dermal regeneration (GHK-Cu), tissue repair (BPC-157, TB-500), neuroprotection (Semax), growth hormone modulation (CJC-1295, ipamorelin), and sexual function (bremelanotide).”
  4. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions“Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.”
  5. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy“This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG ( Ala-Glu-Asp-Gly , Epitalon ) improves the delayed ...”
  6. Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development“Epitalon highly enhances the quality and health of the oocyte, cumulus cell, and post-thawed blastocyst.”
  7. Short Peptides Protect Fibroblast-Derived Induced Pluripotent Stem Cell-Derived Neural Stem Cells from Amyloid-Beta Toxicity“Glu-Asp-Arg (EDR) and Lys-Glu-Asp (KED), and Ala-Glu-Asp-Gly (AEDG) peptides have previously demonstrated neuroprotective effects in various models of ...”