---
slug: humanin
title: "humanin"
kind: standard
status: published
hash: 2096b55e3798a9ace4f85e214911a061d939a65ebaba66608f78f757d3e972e5
created: 2026-06-29T16:58:13.570Z
updated: 2026-10-08T11:49:49.006Z
summary: "Evidence is being populated by Grok web"
tags: []
above: []
below: []
adjacent: []
nested: []
---
# humanin

*Evidence is being populated by Grok web*

## Overview
Evidence is being populated by Grok web search.

## Facts

```json
{
  "converted_from": "markdown",
  "original_updated": "2026-06-29T16:58:14.840Z",
  "register": "standard",
  "category": null
}
```

## Sources

1. [A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders](https://pubmed.ncbi.nlm.nih.gov/39950467/) — “The review primarily highlights that HN is an autophagy inducer, which can promote cell survival in the presence of metabolic and oxidative stress, ...” (sha256 5ef226f7cc216a15)
2. [The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects](https://pubmed.ncbi.nlm.nih.gov/40090538/) — “It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine.” (sha256 484670b0bf44a198)
3. [Humanin improves bone health in a glucocorticoid-treated mouse model](https://pubmed.ncbi.nlm.nih.gov/41550496/) — “We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of ...” (sha256 092164abc7beba4c)
4. [Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...](https://pubmed.ncbi.nlm.nih.gov/39510375/) — “Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...” (sha256 c53438beadf345fb)
5. [Humanin variant P3S is associated with longevity in APOE4 carriers](https://pubmed.ncbi.nlm.nih.gov/38520065/) — “Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.” (sha256 d7755addb27b8761)