---
slug: foxo4-dri
title: "foxo4 dri"
kind: standard
status: published
hash: 0ce16029039cf9283f7a836192b0fc3728d7d8bfd34956009ce0bb409ffda51c
created: 2026-06-29T16:57:13.183Z
updated: 2026-10-08T11:49:49.920Z
summary: "Evidence is being populated by Grok web"
tags: []
above: []
below: []
adjacent: []
nested: []
---
# foxo4 dri

*Evidence is being populated by Grok web*

## Overview
Evidence is being populated by Grok web search.

## Facts

```json
{
  "converted_from": "markdown",
  "original_updated": "2026-06-29T16:57:16.164Z",
  "register": "standard",
  "category": null
}
```

## Sources

1. [FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway](https://pubmed.ncbi.nlm.nih.gov/41625068/) — “Injection of FOXO4-DRI in both naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function.” (sha256 4bfc9e25021cd31b)
2. [The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI](https://pubmed.ncbi.nlm.nih.gov/40593617/) — “This study reveals structural insights into p53 binding to FOXO4/ FOXO4-DRI , informing the development of p53-targeted senolytics for age related diseases.” (sha256 e0fd16ea1fe70d50)
3. [FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation](https://www.nature.com/articles/s42003-025-07738-0) — “FOXO4-DRI shows potential as a treatment targeting the senescence and apoptosis resistance, and holds promise as an approach to prevent the ...” (sha256 a5ae229dbb69a424)
4. [FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells](https://pubmed.ncbi.nlm.nih.gov/39025385/) — “In naturally aged mice, FOXO4-DRI -treated aged mice exhibited increased sperm quality and improved spermatogenesis.” (sha256 3d5c6ef65ef77c7c)