---
slug: epitalon
title: "epitalon"
kind: standard
status: published
hash: 116759cb654d5aee17d0a7ceaafac771e23817302a840ae3adb42a848511ad6e
created: 2026-06-29T16:51:14.796Z
updated: 2026-10-08T11:50:01.137Z
summary: "Evidence is being populated by Grok web"
tags: []
above: []
below: []
adjacent: []
nested: []
---
# epitalon

*Evidence is being populated by Grok web*

## Overview
Evidence is being populated by Grok web search.

## Facts

```json
{
  "converted_from": "markdown",
  "original_updated": "2026-06-29T21:01:54.292Z",
  "register": "standard",
  "category": null
}
```

## Sources

1. [Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties](https://pubmed.ncbi.nlm.nih.gov/40141333/) — “Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution. During the last 25 years, this compound has been extensively studied using in vitro, in vivo, and in silico methods. The results of these studies indicate significant geroprotective and neuroendocrine effects of Epitalone, resulting from its antioxidant, neuro-protective, and antimutagenic effects, originating from both specific and nonspecific mechanisms.” (sha256 62424e795948c57d)
2. [Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity](https://pubmed.ncbi.nlm.nih.gov/40908429/) — “Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. ... Our data suggests that epitalon can extend telomere length in normal healthy mammalian cells through the upregulation of hTERT mRNA expression and telomerase enzyme activity.” (sha256 67850197d9884da5)
3. [Therapeutic peptides in gerontology: mechanisms and applications for healthy aging](https://pubmed.ncbi.nlm.nih.gov/42021992/) — “Nine peptides were identified spanning diverse aging interventions: metabolic restoration (tirzepatide), telomere biology (epitalon), dermal regeneration (GHK-Cu), tissue repair (BPC-157, TB-500), neuroprotection (Semax), growth hormone modulation (CJC-1295, ipamorelin), and sexual function (bremelanotide).” (sha256 b50d1cf0e1f996cc)
4. [Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions](https://pubmed.ncbi.nlm.nih.gov/41490200/) — “Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.” (sha256 ac3e85e0fd49d9b9)
5. [The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy](https://pubmed.ncbi.nlm.nih.gov/40493162/) — “This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG ( Ala-Glu-Asp-Gly , Epitalon ) improves the delayed ...” (sha256 a4d1f93f65ea6178)
6. [Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development](https://pubmed.ncbi.nlm.nih.gov/39788414/) — “Epitalon highly enhances the quality and health of the oocyte, cumulus cell, and post-thawed blastocyst.” (sha256 5824ab328bc2f234)
7. [Short Peptides Protect Fibroblast-Derived Induced Pluripotent Stem Cell-Derived Neural Stem Cells from Amyloid-Beta Toxicity](https://pubmed.ncbi.nlm.nih.gov/39518916/) — “Glu-Asp-Arg (EDR) and Lys-Glu-Asp (KED), and Ala-Glu-Asp-Gly (AEDG) peptides have previously demonstrated neuroprotective effects in various models of ...” (sha256 775bb80c08f2df6c)